Manman Li

Hainan Institute of Biotechnology, Haikou, 570206, Hainan, China
Author    Correspondence author
International Journal of Marine Science, 2024, Vol. 14, No. 6   
Received: 23 Oct., 2024    Accepted: 11 Dec., 2024    Published: 22 Dec., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Vesicular polarity transport plays a critical role in intracellular material transport and organogenesis. This study outlines the fundamental mechanisms of vesicular transport, including budding, trafficking, and fusion, with a particular focus on the significance of polarity in organ formation, especially in establishing apical-basal polarity in epithelial cells, tissue patterning, and morphogenesis. It also explores the molecular regulatory networks involved in vesicular transport, such as Rab GTPases and SNARE proteins, as well as the roles of cytoskeletal elements like actin and microtubules and their spatial regulation. By discussing advancements in experimental models and imaging techniques, this study summarizes effective approaches for investigating vesicular polarity transport. It further highlights the potential applications of emerging technologies in polarity research and their implications for therapeutic development. This comprehensive perspective deepens the understanding of the mechanisms and functions of vesicular polarity transport in organogenesis, providing valuable insights for diagnosing and treating related diseases.

Vesicular polarity transport; Organogenesis; Molecular regulatory networks; Epithelial cell polarity; Imaging techniques