Scientific Commentary

Redefining Intercellular Signaling: Trafficking Mechanism of The Wnt5b-Ror2 Complex in Zebrafish  

Sarah McGrew
International Journal of Aquaculture, Aqua Publisher, Richmond, BC, V7A 4Z5, Canada
Author    Correspondence author
International Journal of Aquaculture, 2024, Vol. 14, No. 1   doi: 10.5376/ija.2024.14.0005
Received: 30 Dec., 2023    Accepted: 12 Feb., 2024    Published: 22 Feb., 2024
© 2024 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

McGrew S., 2024, Redefining intercellular signaling: trafficking mechanism of the Wnt5b-Ror2 complex in zebrafish, International Journal of Aquaculture, 14(1): 37-39 (doi: 10.5376/ija.2024.14.0005)


The article titled "Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish" was written by Steffen Scholpp and other research teams and was published in "Nature" magazine on December 20, 2023. The research team includes a number of biologists and oceanographic experts who are dedicated to uncovering cell signaling mechanisms.This study explores the trafficking mechanism of Wnt5b and Ror2 complexes in zebrafish embryos. Wnt5b is an important ligand in the Wnt signaling pathway, and Ror2 is its receptor. Both of them play a role in cell polarity and migration. The study found that Wnt5b forms a complex with Ror2 in producer cells and is transported from the producer cell to the recipient cell through cell protrusions (called protrusions). Cell protrusions are elongated cell membrane extensions that serve as signaling "highways" to carry signaling molecules from one cell to another.


The research team observed Wnt5b and Ror2 in detail through high-resolution imaging techniques. The results indicate that the Wnt5b-Ror2 complex remains intact during transport and enters the receiving cell via dynein-dependent endocytosis, activating the Wnt-PCP signaling pathway. This mechanism not only enhances the efficiency of signal transmission, but may also influence cell behavior during embryonic development. This study provides new insights into the precise transport of signaling molecules in embryonic development and helps to re-evaluate traditional modes of cell-to-cell communication, which has important applications in aquaculture.

Wnt5b-Ror2; Trafficking mechanism;Zebrafish
[Full-Text PDF] [Full-Text HTML]
International Journal of Aquaculture
• Volume 14
View Options
. PDF(479KB)
Associated material
. Readers' comments
Other articles by authors
. Sarah McGrew
Related articles
. Wnt5b-Ror2
. Trafficking mechanism;Zebrafish
. Email to a friend
. Post a comment